Don't have a TCI SuperCoder account yet? Become a Member >>

Regular Price: $24.95

Ask An Expert Starting at $24.95

Have a medical coding or compliance question? Don’t sacrifice your valuable time to endless research. Choose Ask an Expert to get clear answers from the TCI SuperCoder team. And here’s a tip for the budget-conscious: Select the 12-question pack to get the best rate per question!

Browse Past Questions By Specialty

+View all

NEXT GENERATION SEQUENCING

Apurva Posted Thu 08th of August, 2019 03:29:42 AM
Hi , What CPT codes can be used for NGS UTID test ?
SuperCoder Answered Fri 09th of August, 2019 08:28:15 AM

Hi,

 

The technology used for genomic sequencing is commonly referred to as next-generation sequencing (NGS).

NGS is a technology that provides a method to read many DNA or RNA sequences simultaneously. Also called massive parallel sequencing, the procedure allows the lab analyst to interrogate, or assay, multiple genes or regions of interest within the genome at the same time. This process potentially allows greater ability to identify variant changes that may be relevant to the patient’s clinical situation.

 

CPT codes which are used for genomic sequencing procedures are as follows:

 

81410 - Aortic Dysfunction Or Dilation (Eg, Marfan Syndrome, Loeys Dietz Syndrome, Ehler Danlos Syndrome Type Iv, Arterial Tortuosity Syndrome); Genomic Sequence Analysis Panel, Must Include Sequencing Of At Least 9 Genes, Including Fbn1, Tgfbr1, Tgfbr2, Col3A1, Myh11, Acta2, Slc2A10, Smad3, And Mylk

 

81411 - Aortic Dysfunction Or Dilation (Eg, Marfan Syndrome, Loeys Dietz Syndrome, Ehler Danlos Syndrome Type Iv, Arterial Tortuosity Syndrome); Duplication/Deletion Analysis Panel, Must Include Analyses For Tgfbr1, Tgfbr2, Myh11, And Col3A1

 

81412 - Ashkenazi Jewish Associated Disorders (Eg, Bloom Syndrome, Canavan Disease, Cystic Fibrosis, Familial Dysautonomia, Fanconi Anemia Group C, Gaucher Disease, Tay-Sachs Disease), Genomic Sequence Analysis Panel, Must Include Sequencing Of At Least 9 Genes, Including Aspa, Blm, Cftr, Fancc, Gba, Hexa, Ikbkap, Mcoln1, And Smpd1

 

81413 - Cardiac Ion Channelopathies (Eg, Brugada Syndrome, Long Qt Syndrome, Short Qt Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia); Genomic Sequence Analysis Panel, Must Include Sequencing Of At Least 10 Genes, Including Ank2, Casq2, Cav3, Kcne1, Kcne2, Kcnh2, Kcnj2, Kcnq1, Ryr2, And Scn5A

 

81414 - Cardiac Ion Channelopathies (Eg, Brugada Syndrome, Long Qt Syndrome, Short Qt Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia); Duplication/Deletion Gene Analysis Panel, Must Include Analysis Of At Least 2 Genes, Including Kcnh2 And Kcnq1

 

81415 - Exome (Eg, Unexplained Constitutional Or Heritable Disorder Or Syndrome); Sequence Analysis

 

81416 - Exome (Eg, Unexplained Constitutional Or Heritable Disorder Or Syndrome); Sequence Analysis, Each Comparator Exome (Eg, Parents, Siblings) (List Separately In Addition To Code For Primary Procedure)

 

81417 - Exome (Eg, Unexplained Constitutional Or Heritable Disorder Or Syndrome); Re-Evaluation Of Previously Obtained Exome Sequence (Eg, Updated Knowledge Or Unrelated Condition/Syndrome)

 

81420 - Fetal Chromosomal Aneuploidy (Eg, Trisomy 21, Monosomy X) Genomic Sequence Analysis Panel, Circulating Cell-Free Fetal Dna In Maternal Blood, Must Include Analysis Of Chromosomes 13, 18, And 21

 

81422 - Fetal Chromosomal Microdeletion(S) Genomic Sequence Analysis (Eg, Digeorge Syndrome, Cri-Du-Chat Syndrome), Circulating Cell-Free Fetal Dna In Maternal Blood

 

81425 - Genome (Eg, Unexplained Constitutional Or Heritable Disorder Or Syndrome); Sequence Analysis

 

81426 - Genome (Eg, Unexplained Constitutional Or Heritable Disorder Or Syndrome); Sequence Analysis, Each Comparator Genome (Eg, Parents, Siblings) (List Separately In Addition To Code For Primary Procedure)

 

81427 - Genome (Eg, Unexplained Constitutional Or Heritable Disorder Or Syndrome); Re-Evaluation Of Previously Obtained Genome Sequence (Eg, Updated Knowledge Or Unrelated Condition/Syndrome)

 

81430 - Hearing Loss (Eg, Nonsyndromic Hearing Loss, Usher Syndrome, Pendred Syndrome); Genomic Sequence Analysis Panel, Must Include Sequencing Of At Least 60 Genes, Including Cdh23, Clrn1, Gjb2, Gpr98, Mtrnr1, Myo7A, Myo15A, Pcdh15, Otof, Slc26A4, Tmc1, Tmprss3, Ush1C, Ush1G, Ush2A, And Wfs1

 

81431 - Hearing Loss (Eg, Nonsyndromic Hearing Loss, Usher Syndrome, Pendred Syndrome); Duplication/Deletion Analysis Panel, Must Include Copy Number Analyses For Strc And Dfnb1 Deletions In Gjb2 And Gjb6 Genes

 

81432 - Hereditary Breast Cancer-Related Disorders (Eg, Hereditary Breast Cancer, Hereditary Ovarian Cancer, Hereditary Endometrial Cancer); Genomic Sequence Analysis Panel, Must Include Sequencing Of At Least 10 Genes, Always Including Brca1, Brca2, Cdh1, Mlh1, Msh2, Msh6, Palb2, Pten, Stk11, And Tp53

 

81433 - Hereditary Breast Cancer-Related Disorders (Eg, Hereditary Breast Cancer, Hereditary Ovarian Cancer, Hereditary Endometrial Cancer); Duplication/Deletion Analysis Panel, Must Include Analyses For Brca1, Brca2, Mlh1, Msh2, And Stk11

 

81434 - Hereditary Retinal Disorders (Eg, Retinitis Pigmentosa, Leber Congenital Amaurosis, Cone-Rod Dystrophy), Genomic Sequence Analysis Panel, Must Include Sequencing Of At Least 15 Genes, Including Abca4, Cnga1, Crb1, Eys, Pde6A, Pde6B, Prpf31, Prph2, Rdh12, Rho, Rp1, Rp2, Rpe65, Rpgr, And Ush2A

 

81435 - Hereditary Colon Cancer Disorders (Eg, Lynch Syndrome, Pten Hamartoma Syndrome, Cowden Syndrome, Familial Adenomatosis Polyposis); Genomic Sequence Analysis Panel, Must Include Sequencing Of At Least 10 Genes, Including Apc, Bmpr1A, Cdh1, Mlh1, Msh2, Msh6, Mutyh, Pten, Smad4, And Stk11

 

81436 - Hereditary Colon Cancer Disorders (Eg, Lynch Syndrome, Pten Hamartoma Syndrome, Cowden Syndrome, Familial Adenomatosis Polyposis); Duplication/Deletion Analysis Panel, Must Include Analysis Of At Least 5 Genes, Including Mlh1, Msh2, Epcam, Smad4, And Stk11

 

81437 - Hereditary Neuroendocrine Tumor Disorders (Eg, Medullary Thyroid Carcinoma, Parathyroid Carcinoma, Malignant Pheochromocytoma Or Paraganglioma); Genomic Sequence Analysis Panel, Must Include Sequencing Of At Least 6 Genes, Including Max, Sdhb, Sdhc, Sdhd, Tmem127, And Vhl

 

81438 - Hereditary Neuroendocrine Tumor Disorders (Eg, Medullary Thyroid Carcinoma, Parathyroid Carcinoma, Malignant Pheochromocytoma Or Paraganglioma); Duplication/Deletion Analysis Panel, Must Include Analyses For Sdhb, Sdhc, Sdhd, And Vhl

 

81439 - Hereditary Cardiomyopathy (Eg, Hypertrophic Cardiomyopathy, Dilated Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy), Genomic Sequence Analysis Panel, Must Include Sequencing Of At Least 5 Cardiomyopathy-Related Genes (Eg, Dsg2, Mybpc3, Myh7, Pkp2, Ttn)

 

81440 - Nuclear Encoded Mitochondrial Genes (Eg, Neurologic Or Myopathic Phenotypes), Genomic Sequence Panel, Must Include Analysis Of At Least 100 Genes, Including Bcs1L, C10Orf2, Coq2, Cox10, Dguok, Mpv17, Opa1, Pdss2, Polg, Polg2, Rrm2B, Sco1, Sco2, Slc25A4, Sucla2, Suclg1, Taz, Tk2, And Tymp

 

81442 - Noonan Spectrum Disorders (Eg, Noonan Syndrome, Cardio-Facio-Cutaneous Syndrome, Costello Syndrome, Leopard Syndrome, Noonan-Like Syndrome), Genomic Sequence Analysis Panel, Must Include Sequencing Of At Least 12 Genes, Including Braf, Cbl, Hras, Kras, Map2K1, Map2K2, Nras, Ptpn11, Raf1, Rit1, Shoc2, And Sos1

 

81443 - Genetic Testing For Severe Inherited Conditions (Eg, Cystic Fibrosis, Ashkenazi Jewish-Associated Disorders [Eg, Bloom Syndrome, Canavan Disease, Fanconi Anemia Type C, Mucolipidosis Type Vi, Gaucher Disease, Tay-Sachs Disease], Beta Hemoglobinopathies, Phenylketonuria, Galactosemia), Genomic Sequence Analysis Panel, Must Include Sequencing Of At Least 15 Genes (Eg, Acadm, Arsa, Aspa, Atp7B, Bckdha, Bckdhb, Blm, Cftr, Dhcr7, Fancc, G6Pc, Gaa, Galt, Gba, Gbe1, Hbb, Hexa, Ikbkap, Mcoln1, Pah)

 

81445 - Targeted Genomic Sequence Analysis Panel, Solid Organ Neoplasm, Dna Analysis, And Rna Analysis When Performed, 5-50 Genes (Eg, Alk, Braf, Cdkn2A, Egfr, Erbb2, Kit, Kras, Nras, Met, Pdgfra, Pdgfrb, Pgr, Pik3Ca, Pten, Ret), Interrogation For Sequence Variants And Copy Number Variants Or Rearrangements, If Performed

 

81448 - Hereditary Peripheral Neuropathies (Eg, Charcot-Marie-Tooth, Spastic Paraplegia), Genomic Sequence Analysis Panel, Must Include Sequencing Of At Least 5 Peripheral Neuropathy-Related Genes (Eg, Bscl2, Gjb1, Mfn2, Mpz, Reep1, Spast, Spg11, Sptlc1)

 

81450 - Targeted Genomic Sequence Analysis Panel, Hematolymphoid Neoplasm Or Disorder, Dna Analysis, And Rna Analysis When Performed, 5-50 Genes (Eg, Braf, Cebpa, Dnmt3A, Ezh2, Flt3, Idh1, Idh2, Jak2, Kras, Kit, Mll, Nras, Npm1, Notch1), Interrogation For Sequence Variants, And Copy Number Variants Or Rearrangements, Or Isoform Expression Or Mrna Expression Levels, If Performed

 

81455 - Targeted Genomic Sequence Analysis Panel, Solid Organ Or Hematolymphoid Neoplasm, Dna Analysis, And Rna Analysis When Performed, 51 Or Greater Genes (Eg, Alk, Braf, Cdkn2A, Cebpa, Dnmt3A, Egfr, Erbb2, Ezh2, Flt3, Idh1, Idh2, Jak2, Kit, Kras, Mll, Npm1, Nras, Met, Notch1, Pdgfra, Pdgfrb, Pgr, Pik3Ca, Pten, Ret), Interrogation For Sequence Variants And Copy Number Variants Or Rearrangements, If Performed

 

81460 - Whole Mitochondrial Genome (Eg, Leigh Syndrome, Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes [Melas], Myoclonic Epilepsy With Ragged-Red Fibers [Merff], Neuropathy, Ataxia, And Retinitis Pigmentosa [Narp], Leber Hereditary Optic Neuropathy [Lhon]), Genomic Sequence, Must Include Sequence Analysis Of Entire Mitochondrial Genome With Heteroplasmy Detection

 

81465 - Whole Mitochondrial Genome Large Deletion Analysis Panel (Eg, Kearns-Sayre Syndrome, Chronic Progressive External Ophthalmoplegia), Including Heteroplasmy Detection, If Performed

 

81470 - X-Linked Intellectual Disability (Xlid) (Eg, Syndromic And Non-Syndromic Xlid); Genomic Sequence Analysis Panel, Must Include Sequencing Of At Least 60 Genes, Including Arx, Atrx, Cdkl5, Fgd1, Fmr1, Huwe1, Il1Rapl, Kdm5C, L1Cam, Mecp2, Med12, Mid1, Ocrl, Rps6Ka3, And Slc16A2

 

81471 - X-Linked Intellectual Disability (Xlid) (Eg, Syndromic And Non-Syndromic Xlid); Duplication/Deletion Gene Analysis, Must Include Analysis Of At Least 60 Genes, Including Arx, Atrx, Cdkl5, Fgd1, Fmr1, Huwe1, Il1Rapl, Kdm5C, L1Cam, Mecp2, Med12, Mid1, Ocrl, Rps6Ka3, And Slc16A2

 

 

Thanks

Related Topics